Figure 2

Role of the Kidneys in the Regulation of Intra-and Extra-Renal Blood Pressure

Seriki A Samue*, Adebayo O Francis and Odetola O Anthony

Published: 17 July, 2018 | Volume 2 - Issue 1 | Pages: 048-058

ach-aid1011-g002

Figure 2:

A model for local control of RAS activity within the kidney- High levels of angiotensin II (ANGII) in circulation, derived from angiotensinogen (AGT) generated primarily by the liver, are associated with; increased ANGII in the kidney, up regulation of AGT in the proximal tubule epithelium, increased levels of AGT in the tubular lumen, generation of ANGII requiring angiotensin-converting enzyme (ACE) expression in the brush border of the proximal tubule (PT), and increased excretion of AGT and ANG peptides in urine [39].

Read Full Article HTML DOI: 10.29328/journal.ach.1001011 Cite this Article Read Full Article PDF

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