Table of Contents

Differentiation of the Non-dipping Blood Pressure Phenotype in Obstructive Sleep Apnea: An Observational Study

Published on: 15th May, 2025

Background: Absence of nocturnal decrease in Blood Pressure (BP) (“non-dipping”) has been shown to be a strong and independent predictor of cardiovascular events, target organ damage, cardiovascular sequela and cardiovascular mortality. Obstructive Sleep Apnea (OSA) has been associated with non-dipping with an estimated prevalence of approximately 50%, but factors associated with non-dipping in OSA patients remain poorly understood. In this study, we examined clinically relevant variables associated with non-dipping in OSA.Methods: Patients (n = 35) undergoing overnight valuation for OSA, laboratory-based polysomnography, structured clinical interviews, and comprehensive metabolic and anthropometric evaluations, and ambulatory BP monitoring for 24 hours. Patients were classified into a) dipping BP group or b) non-dipping BP group, based on (a) a nocturnal systolic BP decrease of 10% - 20% or (b) a systolic BP decrease of < 10%. Results: Patients had moderate and severe OSA (AHI = 34.8 ± 29.1), and 42.9% demonstrated a non-dipping BP pattern. The severity of OSA measures did not differ between dipping group and non-dipping group. However, Wake after Sleep Onset (WASO) and chronicity of insomnia predicts non-dipping BP independent of demographics, sleep stages, anthropometrics, metabolic measures, or arterial stiffness. Conclusion: These findings contribute to a better understanding of the cardiovascular impacts of OSA and indicate that sleep quality should be incorporated into clinical assessments and management of OSA patients.
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Non-adherence to Drug Therapy for Hypertension is Critical and Underestimated in Mexican Patients: A Study from the First Contact Level

Published on: 10th July, 2025

Adherence, in a healthcare context, refers to the extent to which a person’s behavior aligns with recommendations from a healthcare provider. This can involve taking medication as prescribed, following a specific diet, or adhering to lifestyle changes. Although it is known that adherence is critical and requires a special approach to health, in Mexico, there are few studies on this issue. We confirm the information collected from 786 patients using an original questionnaire (AFEC) in Spanish, previously validated. Perfect adherence was detected in only 179 (22.8%), good adherence in 334 (42.5%), and nonadherence in 452 (57.5%). The age, obesity, and number of comorbidities were significantly associated with non-adherence (p < 0.05). Special strategies to approach this critical problem in health need to be reconsidered in Mexico. Non-adherence may help explain the low control rate of Mexican patients and the high rate of cardiovascular mortality.
Cite this ArticleCrossMarkPublonsHarvard Library HOLLISGrowKudosResearchGateBase SearchOAI PMHAcademic MicrosoftScilitSemantic ScholarUniversite de ParisUW LibrariesSJSU King LibrarySJSU King LibraryNUS LibraryMcGillDET KGL BIBLiOTEKJCU DiscoveryUniversidad De LimaWorldCatVU on WorldCat
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